Application of crop protection materials is one of the crucial operations in agriculture to meet ever demanding food production. The drone mounted sprayer mainly consists of BLDC motors, LiPo (Lithium polymer) batteries, peticide tank, pump, and supporting frame. Six BLDC motors were mounted to hexa-copter frame to lift of 5 kg payload capacity. Two LiPo batteries of 6 cells – 8000mAh were used to supply the necessary current required for the propulsion system. A 5 liter capacity conical-square shaped fluid tank was used to hold the pesticide solution. A 12 V DC motor coupled with pump was used to pressurize spray liquid and then to atomize in to fine spray droplets by means of four nozzles. A suitable aluminium supporting frame was used to mount the spray liquid tank, sprayer motor, spray and supporting legs (landing gears) for safe take-off and landing. The entire drone mounted sprayer operation controlling with the help of transmitter at ground level, HD FPV camera also provide at front down side of drone sprayer unit to monitoring the live spaying operation.